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OCR: Steps in Antibody Production Cell Activity Antigen- -bearing agents enter tissues B.cel becomes activated when encounters an antigen that fits its antigen rece eptors either alone or more often in conjunction with helper cells Activated oel proliferates, enlarging its clone Some of the newly formed B cells differentiate further to become plasma cells 5 Plasma cells synthesize and secrete antibodies whose molecular structure similar to the activated cell's antigen rece eptors Antibodies combine with antigen- bearing agents helping to destroy them T Cell Activity Antigen- -bearina agents enter tissues Accessory cell. such as a macrophage phagocytizes antigen- bearing agent, and the macrophage's lysosomes digest the agent. Antigens from the digested antigen- -bearing agents are displayed on t ...